As the NASCAR Cup Series contests its playoff opener at Darlington Raceway, a total of 36 cars will make up the starting field for Sunday's Cook Out Southern 500 at the 1.366-mile facility.
Notable drivers in one of the so-called 'crown jewel' events of the NASCAR Cup Series season include JJ Yeley (No. 15, Rick Ware Racing), Ryan Newman (No. 51, Rick Ware Racing), and BJ McLeod (No. 78, Live Fast Motorsports).
NASCAR Cup Series Cook Out Southern 500 Entry List
| Entry | # | Driver | Sponsor | Manu | Team | Crew Chief |
| 1 | 1 | Ross Chastain | Unishippers | Chevrolet | Trackhouse Racing | Phil Surgen |
| 2 | 2 | Austin Cindric | Discount Tire | Ford | Team Penske | Brian Wilson |
| 3 | 3 | Austin Dillon | Morgan & Morgan | Chevrolet | Richard Childress Racing | Keith Rodden |
| 4 | 4 | Kevin Harvick | Mobil 1 Take 5 | Ford | Stewart-Haas Racing | Rodney Childers |
| 5 | 5 | Kyle Larson | HendrickCars.com | Chevrolet | Hendrick Motorsports | Cliff Daniels |
| 6 | 6 | Brad Keselowski | Solomon Plumbing | Ford | RFK Racing | Matt McCall |
| 7 | 7 | Corey LaJoie | Gainbridge | Chevrolet | Spire Motorsports | Ryan Sparks |
| 8 | 8 | Kyle Busch | McLaren Custom Grills | Chevrolet | Richard Childress Racing | Randall Burnett |
| 9 | 9 | Chase Elliott | NAPA Auto Parts | Chevrolet | Hendrick Motorsports | Alan Gustafson |
| 10 | 10 | Aric Almirola | Smithfield Foods | Ford | Stewart-Haas Racing | Drew Blickensderfer |
| 11 | 11 | Denny Hamlin | SportClips Haircuts | Toyota | Joe Gibbs Racing | Chris Gabehart |
| 12 | 12 | Ryan Blaney | Menards / Richmond Water Heaters | Ford | Team Penske | Jonathan Hassler |
| 13 | 14 | Chase Briscoe | HighPoint.com | Ford | Stewart-Haas Racing | Richard Boswell |
| 14 | 15 | JJ Yeley | TBA | Ford | Rick Ware Racing | Jerry Kelley |
| 15 | 16 | AJ Allmendinger | TBA | Chevrolet | Kaulig Racing | Matt Swiderski |
| 16 | 17 | Chris Buescher | BuildSubmarines.com | Ford | RFK Racing | Scott Graves |
| 17 | 19 | Martin Truex, Jr. | Bass Pro Shops | Toyota | Joe Gibbs Racing | James Small |
| 18 | 20 | Christopher Bell | Yahoo! | Toyota | Joe Gibbs Racing | Adam Stevens |
| 19 | 21 | Harrison Burton | Motorcraft / Quick Lane | Ford | Wood Brothers Racing | Jeremy Bullins |
| 20 | 22 | Joey Logano | Shell-Pennzoil | Ford | Team Penske | Paul Wolfe |
| 21 | 23 | Bubba Wallace | McDonald's | Toyota | 23XI Racing | Bootie Barker |
| 22 | 24 | William Byron | Liberty University | Chevrolet | Hendrick Motorsports | Rudy Fugle |
| 23 | 31 | Justin Haley | TBA | Chevrolet | Kaulig Racing | Trent Owens |
| 24 | 34 | Michael McDowell | StageFront.VIP | Ford | Front Row Motorsport | Travis Peterson |
| 25 | 38 | Todd Gilliland | Quincy Compressor | Ford | Front Row Motorsport | Ryan Bergenty |
| 26 | 41 | Ryan Preece | HaasTooling.com | Ford | Stewart-Haas Racing | Chad Johnston |
| 27 | 42 | Carson Hocevar | Sunseeker Resorts | Chevrolet | LEGACY MOTOR CLUB | Luke Lambert |
| 28 | 43 | Erik Jones | Allegiant | Chevrolet | LEGACY MOTOR CLUB | Dave Elenz |
| 29 | 45 | Tyler Reddick | Jordan Brand | Toyota | 23XI Racing | Billy Scott |
| 30 | 47 | Ricky Stenhouse, Jr. | Boost by Kroger / Irish Spring | Chevrolet | JTG Daugherty Racing | Mike Kelley |
| 31 | 48 | Alex Bowman | Ally Financial | Chevrolet | Hendrick Motorsports | Blake Harris |
| 32 | 51 | TBA | Parts Plus / Biohaven | Ford | Rick Ware Racing | Billy Plourde |
| 33 | 54 | Ty Gibbs | Monster Energy | Toyota | Joe Gibbs Racing | Chris Gayle |
| 34 | 77 | Ty Dillon | Raze Energy Blue Shock | Chevrolet | Spire Motorsports | "Kevin ""Bono"" Manion" |
| 35 | 78 | BJ McLeod | Affliction | Chevrolet | Live Fast Motorsports | David Ingram |
| 36 | 99 | Daniel Suarez | Freeway.com | Chevrolet | Trackhouse Racing | Travis Mack |
